EXPLORE
HOW EHCP & PROBIOTIC LGG^® WORKS IN CMPA MANAGEMENT

CMPA=cow’s milk protein allergy. EHCP=extensively hydrolyzed casein protein. LGG^®=Lacticaseibacillus rhamnosus GG.

VIEW NUTRITIONAL MANAGEMENT OF CMPA IN ACTION

See how EHCP and the probiotic LGG^® work together to quickly provide relief and reduce the chance of future allergic manifestations.

CMPA
PATHOGENESIS

IMBALANCED MICROBIOTA

INCREASED INTESTINAL PERMEABILITY

Overactive immune response

CMPA MANAGEMENT
WITH EHCP & LGG^®

IMPROVED MICROBIOTA PROFILE

STRENGTHENED INTESTINAL BARRIER

Reduced allergic response

EHCP

LGG^®

Clinical Evidence

Key Takeaways

IMBALANCED MICROBIOTA

When the gut microbiome is imbalanced, it can disrupt the mucus layer, increase intestinal permeability, and cause inflammation - — — — - — which can lead to CMPA in infants. 1-6

1. Berni Canani R, et al. Front Immunol. 2019;19:191. 2. Berni Canani R, et al. Sci Rep. 2018;8(1):12500. 3. Akagawa S, Kaneko K. Allergol Int. 2022;71:301-309. 4. Nance CL, et al. Children (Basel). 2020;7(6):50. 5. Di Costanzo M, et al. Life (Basel). 2021;11(5):384. 6. Pascal M, et al. Front Immunol. 2018;9:1584.

EHCP & LGG^®: Clinical Evidence in CMPA Management

FAST RELIEF: STARTS TO REDUCE EXCESSIVE CRYING* IN LESS THAN 24 HOURS¹

*Within 48 hours of switching from cow's milk-based formula to EHCP formula, 90% of colicky infants experienced reduced crying.¹

The Improvement of CMPA Manifestations

In a 2023 prospective cohort analysis of data collected by HCPs from 202 infants under 6 months of age, who were diagnosed or suspected of having CMPA and exhibited related manifestations, significant improvement was observed within 3 to 6 weeks of starting nutritional management with EHCP & LGG^®².

HELPS REDUCE THE CHANCE OF FUTURE ALLERGIC MANIFESTATIONS

Infants on EHCP & LGG^® formula may be 2.3 times less likely to have allergies after 36 months follow-up, such as asthma, eczema, urticaria, and rhinoconjunctivitis.³

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2

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1. Lothe L, Lindberg T. Pediatrics. 1989;83(2):262-266.

*Within 48 hours when managing colic due to cow's milk allergy. Studied before the addition of DHA, ARA, or LGG^®.
ARA=arachidonic acid. DHA=docosahexaenoic acid. HCP=health care provider.

2. Wilsey 2023, et al. Nutrients. 2023;15(7):1677.

3. Nocerino R, et al. J Pediatr. 2021;232:183-191.

Key Takeaways